Alteration of neuro-dopamine and steroid hormone homeostasis in wild Bank voles in relation to tissue concentrations of PFAS at a Nordic skiing area

Perfluoroalkyl substances (PFAS) are contaminants that applied in a wide range of consumer products, including ski products. The present study investigated the neuro-dopamine (DA) and cellular steroid hormone homeostasis wild Bank voles (Myodes glareolus) from skiing area Norway (Trondheim), relation to tissue concentrations PFAS. We found positive association between brain DA concentration several PFAS, while there was negative PFAS dopamine receptor 1 (dr1) mRNA. ratio its metabolites (3,4-dihydroxyphenylacetic acid: DOPAC homovanillic HVA) showed DOPAC/DA suggesting altered metabolism via monoamine oxidase (Mao). This assumption is supported by an observed mao mRNA Previous studies have shown can indirectly regulate estrogen (E2) testosterone (T) biosynthesis. no levels, some T concentrations, might affect through other mechanisms. results current indicate may alter neuro-DA voles, with potential consequences on reproduction general health.